Analysis on the Critical Issues of UV Light Induced Corneal Cross Linking
نویسنده
چکیده
A dynamic model of UV light photoinitiated cross linking in corneal collagen is presented to analyze the critical issues involved in the procedure. These issues include the dynamics of the UV light penetration and the safety depth margin (z*), the roles of the UV light intensity, concentration and extinction coefficient of the initiator. Analytic formulas are developed to show that z* is a decreasing function of the extinction coefficient and the concentration of the initiator, but it is a nonlinearly increasing function of the light intensity and irradiation time. Our analytic formulas are used to analyze the measured data showing the dynamic feature of the light intensity. Finally, a new protocol is suggested based on our theoretical and experimental finding.
منابع مشابه
Analytic Formulas for the Clinical Issues of a UV-Light-Activated Corneal Crosslinking Device
Objective: Modeling the critical issues of the dynamics of UV-light-initiated crosslinking of corneal collagen including the new safety criteria, crosslinking time and the efficacy. Methods: A coupled dynamic equations is numerically solved and analytic formulas are derived for three critical parameters: the safety dose (E*), the cross linking time (T*) and the efficacy defined by the increase ...
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